Doctors Best Quercetin-Bromelain supplies the flavonoid quercetin extracted from seed pods of the Dimorphandra mollis plant.
Flavonoids are “semi-essential” nutrients found in many plants and foods. Bromelain is an enzyme complex derived from the pineapple stem. Bromelain supports tissue comfort and may enhance quercetin absorption.
Quercetin belongs to the flavonol subgroup of bioflavonoids, a class of compounds that are widely (and colorfully) distributed in plants commonly consumed in the human diet. A brilliant bright yellow compound in its isolated form, quercetin is found in especially high levels (per serving) in onions, kale, tomatoes, and apples. Flavonols, including quercetin, are believed to present specific actions in contributing to the widely known health benefits of fruit and vegetable consumption.
Bromelain is an enzyme complex derived from the pineapple stem. (Note: G.D.U. stands for “Gelatin-Digesting Units,” a commonly accepted measure of enzyme activity).
Flavonoids are some of the most abundant and diversely acting ingredients in nature. Despite a staggering accumulation of quercetin literature to date, there is still a long way to go in clinically studying this compound to confirm the preclinical evidence that suggests numerous avenues of health promotion. While the initial focus was on the radical-scavenging abilities of quercetin, it is still unclear to what extent the potential of this characteristic is realized within the human body. Nonetheless, the totality of notable scientific studies together indicates benefits of increased dietary quercetin.
May Support a Healthy Cardiovascular System
Scientific interest towards quercetin’s potential to support the cardiovascular system was in part generated by results of the epidemiological Zutphen Elderly Study, which suggested that an increased intake of flavonoids, principally represented by intake of quercetin from tea, onions, and apples, was a factor associated with superior cardiovascular health in the participating elderly men. The finding was still significant when adjustments were made for other factors such as age, smoking, blood lipid profile, blood pressure, body-mass index, physical activity, and intake of dietary fiber and other antioxidants like vitamin C and vitamin E.
May Support a Healthy Respiratory System
Human epidemiologic research suggests a relationship between quercetin intake and healthy lung function. In vitro and animal research models are largely in agreement with this finding, also suggesting mechanisms by which quercetin may support healthy respiratory function. Currently, there is some evidence from human studies suggesting that the respiratory system might be supported by quercetin intake, particularly when quercetin is given with vitamin C (a common combination in many food sources of quercetin). For instance, in a randomized, double-blinded, placebo-controlled study of 1,002 participants, the combination of 1,000 mg per day of quercetin with 1,000 mg of vitamin C (plus niacin) for 12 weeks produced some benefit in this area of health among a subgroup of participants over the age of 40 who rated themselves as physically fit. There is also some hope that quercetin may help promote healthy airway function in other ways; at least in preliminary work in guinea pigs, quercetin showed a propensity for helping respiratory function of the guinea pigs when challenged with a substance to which the guinea pigs had been sensitized. Additionally, a recent mouse model has generated some anticipation that quercetin may support healthy airway function by maintaining a healthy balance of immune system cells within the respiratory system. A fairly similar mouse study using Bromelain found that this ingredient also achieved desirable physiological effects.
Bromelain to Enhance Quercetin
Bromelain has been used in conjunction with quercetin experimentally, as researchers have reason to believe that bromelain may enhance the transport of the bioflavonoids (like quercetin) across the intestinal membrane. At the end of a randomized, double-blinded, placebo-controlled study where participants were administered 500 mg quercetin twice daily, the researchers continued with an open-label style study that supplemented the 500 mg quercetin twice daily with bromelain and papain also. The bromelain and papain apparently contributed greatly to the desired outcome, improving upon the results from quercetin given alone.
Directions and Use
Take 2 capsules three times daily, preferably 30 to 60 minutes before meals.
Serving Size: 2 Veggie capsules
Serving per container: 90 servings
Amount per serving % Daily Value
Quercetin (as Quercetin Dihydate) 500 mg †
Bromelain 250 mg †
(Enzyme activity: 2400 GDU [Gelatin Digesting Units] per gram)
† Daily Value not established.
Modified cellulose (vegetarian capsule), rice powder, magnesium stearate (vegetable source), silicon dioxide.